potentially revolutionizing chronic pain treatment and GPCR drug design. Previously, authors have identified GW461484A (GW) as an inhibitor of the kinase Yck2 in the fungal pathogen Candida albicans.

Each cell in your body relies on precise communication with other cells to function properly. At the center of this process ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Our lab is dedicated to uncovering how genetic variations shape protein structure, function, and cellular signaling, ultimately influencing drug responsiveness. By exploring the dynamic nature of ...

Paladines et al. demonstrated that the anti-inflammatory action exerted by extracellular adenosine in human gingival fibroblasts is mediated by the activation of A 2A receptors and by subsequent ...

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