In summary, our study delineates a mechanism initiated by β-CTF that can induce synaptic degeneration in a cell-autonomous manner, thus extending beyond the scope of Aβ antibody-based therapies ...

B Representative images showing immunofluorescence staining of expressed GFP or β-CTF-HA by AAV in mouse hippocampi (WT). Scare bars represent 1000 μm (left) and 500 μm (right). C Images of mouse ...

Sheep anti-NS5A polyclonal serum (1:2000, from Mark Harris, Leeds),42 mouse anti-EBV EA-D clone (0261) (Santa Cruz, 1:100), Alexa Fluor-conjugated secondary antibodies (Invitrogen, 1:200) or direct ...

Their goal was to create a more powerful antibody treatment against influenza A, one of the most common and deadly strains of the virus. What they discovered could change how people are protected ...

The researchers showed "super antibodies" from the man's blood prevented toxic damage from neurotoxins found in the venoms of 19 different snake species, including mambas and cobras. Even so ...

Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope. Cell Reports , 2025; 44 (4): 115331 DOI: 10.1016/j.celrep.2025.115331 Cite This Page : ...

The researchers showed “super antibodies” from the man’s blood prevented toxic damage from neurotoxins found in the venoms of 19 different snake species. Scientists in the United States have ...

Helen Branswell covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development. Follow her on Mastodon and Bluesky. You can reach Helen ...

AJMC Insights Series features Kathleen Moore, MD, MS, a gynecologic oncologist and expert in ovarian cancer treatment. Dr Moore discusses various aspects of novel therapies for ovarian cancer ...

The potential of monoclonal antibodies (mAbs) as therapies is indisputable. The current mAbs market is expected to be around ~USD 150 billion. In 2021, five out of the top 10 selling drugs were ...