Viral-mediated Oct4 overexpression induces direct conversion of wildtype mammalian Müller glia to bipolar neurons, and this process is synergistically enhanced by loss of Notch signaling.

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

Their goal was to create a more powerful antibody treatment against influenza A, one of the most common and deadly strains of the virus. What they discovered could change how people are protected ...

The potential of monoclonal antibodies (mAbs) as therapies is indisputable. The current mAbs market is expected to be around ~USD 150 billion. In 2021, five out of the top 10 selling drugs were ...

The FDA has said it intends to reduce or replace animal testing of some medicines, including monoclonal antibodies, with other methods that it hopes will be more relevant to human physiology.

A new online validation initiative pairs structural and functional insights to help scientists map epitopes in a 3D context, enhancing antibody-based assay efficiency and accuracy. New approaches pair ...

Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world ...

A specific antibody can indicate which patients with lupus are at higher risk for heart attacks, strokes and other blood clots, new research from @jhrheumatology shows › Some patients with lupus who ...

However, since the discovery of NMO-IgG or aquaporin-4 (AQP4) antibody (AQP4-antibody), an NMO-specific autoantibody to AQP4, the dominant water channel in the central nervous system densely expressed ...