News

University of Geneva4h
The subcellular signaling landscape of receptors
The subcellular signaling landscape of receptors. G protein-coupled receptors (GPCRs) form the largest receptor family in humans. GPCRs mediate the effects of diverse natural liga ...
Bioage Expands APJ Agonist Pipeline With Oral Small-Molecule And Long-Acting Biologic Candidates
Company enters option agreement with JiKang Therapeutics to in-license novel APJ agonist antibody New composition of matter IP filed for ch ...
gut.bmj3d
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice
G-protein-coupled receptor kinase 6 (GRK6) is an intracellular kinase that regulates the sensitivity of certain G-protein-coupled receptors, including those involved in the migration of inflammatory ...
eLife4d
Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface
Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...
Septerna to Present at Jefferies Global Healthcare Conference
Septerna, Inc. (Nasdaq: SEPN), a biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that Jeffrey Finer, M.D., Ph.D., Chief Executive ...