Given the known benefits of heart rate reduction for cardiac disease, coupled with the intolerability of current options in many patients, ivabradine may be a significant addition to the ...

The slower heart rate isn’t as funny — it has fewer funny channels to transmit current that controls the activity of the heart cells. The results suggest a mechanism for sinus bradycardia in ...

Ivabradine slows the rate of the heart by inhibiting the so-called "funny" current within the heart's natural pacemaker, the sinoatrial node. The main basis for Amgen's application will be the ...

Pacemaker cells in the sinoatrial node control heart rate, but what controls the ... regarding the relative contributions of the 'funny current' generated by ion channels and the RyR dependent ...

Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing non-cardiac surgery: a phase IIa, triple blind, placebo controlled randomised trial ...