The study evaluated a reduced-intensity conditioning regimen without total body irradiation for alloHCT in DC/TBD patients. Non-TBI patients showed similar graft failure, GVHD, and overall ...

Dyskeratosis congenita has historically been characterized by a triad of abnormalities in the skin, nails and oral mucosa but can also include pulmonary and liver disease,” said Kasiani C. Myers, M.D.

Dyskeratosis congenita (DKC) is a rare condition marked by progressive failure of the bone marrow, the spongy tissue inside the bones that is essential for the production of new cells. The cells that ...

Short telomeres are a principal defining feature of telomere biology disorders, such as dyskeratosis congenita (DC), for which there are ... were measured by flow cytometry from three replicates. E.

A link between telomeres and a molecular signaling cascade called the Wnt pathway has been identified by researchers, which may point to a treatment option for dyskeratosis congenita patients.

This may, in some cases, lead to increased morbidity and mortality. Flow-FISH and Q-FISH measurement of leucocyte telomere length are currently only available as a diagnostic method in a few labs ...

Flow-FISH can measure the telomere length in ... The childhood syndrome dyskeratosis congenita is characterized clinically by the mucocutaneous triad of nail dystrophy (Panel A), reticular skin ...

Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant dyskeratosis congenita, a rare hereditary ...