Researchers led by Maike Sander, scientific director of the Max Delbrück Center, have developed a vascularized organoid model ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Crosstalk between the AKT and ERK signaling cascades allows context-dependent fine-tuned control of lymphatic endothelial cell function. As suggested by the studies in the previous paragraph, ...

Endothelial cells (ECs) sense blood flow and respond to the mechanical ... Our unbiased transcriptional profiling results show that KLF2 inhibits the BMP/SMAD1/5 pathway in ECs, thereby protects ...

Mutations disrupting Norrin signaling ... 5 biological replicates. Significance was calculated by one‐way ANOVA with Bonferroni’s multiple comparisons test (*P < 0.05 as compared with NT). B. RT–qPCR ...

A variety of different signals induce specific responses through a common, extracellular-signal regulated ... methods of evaluating ERK by treating PC-12 cells with EGF and harvesting cells before ...

Interactions between serotonergic and purinergic signaling in gut physiology. Mechanical stress activates a mechanosensor on EC to release 5-HT that has a myriad ... manner in human blood vessel ...

Primary antibodies against phosphorylated JNK, BMP2 (Cell Signaling Technology, Beverly, MA, USA), ERK (GeneTex, Inc., Irvine, CA, USA), p38 MAP kinase and Smad 1/5/8 (Santa Cruz Biotechnology ...

Scale bar, 100 μm. ERK 1/2 Signaling Is Activated Via VEGF and Plays a Role in Cell Death by OGD Figure 5. VEGF acts via ERK 1/2 signaling. A, Endothelial cell treatment with 10 μg/mL of the ...