The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers at UZH have now shown ...

Due to the sudden rupture of the aortic wall, aortic dissection is a life-threatening condition that requires immediate ...

In typical ALI/ARDS, the inflammatory response is primarily localized to the lungs, while sepsis-induced ALI/ARDS elicits a robust systemic immune response due to infection, resulting in more severe ...

This state is mediated by a receptor on endothelial cells called Tie2. Under normal conditions, ANGPT2 prompts Tie2 to produce an anti-inflammatory response. However, these conditions are reversed ...

Deletion of YAP in endothelial cells also markedly augmented the inflammatory response and cardiovascular dysfunction in a polymicrobial sepsis model induced by cecal ligation and puncture. YAP ...

In summary, the study reveals how sepsis-induced lactate production activates endothelial cells and promotes ferroptosis through H3K14 lactylation, ultimately leading to vascular injury and lung ...

The reason for organ failure in sepsis patients is because the endothelial cells lining blood vessels become leaky, resulting in abnormal fluid shifts which ultimately shut down the blood supply.

Plasma biomarker levels, indicating inflammation, endothelial cell activation, and coagulation activation, showed no significant differences between MS1 groups. In 215 ICU patients without infection, ...

Interestingly, genes related to septic shock were mainly involved in the immune system and endothelial cells, while genes related to non-septic shock were primarily associated with endothelial cells.

The general pathology involves increased permeability of the endothelial cells of the pulmonary capillary and of the epithelial cells of the alveoli. Sepsis induced ARDS is often caused by ...

The pathophysiology of sepsis-AKI involves multiple cell types, including macrophages, vascular endothelial cells (ECs) and renal tubular epithelial cells (TECs), etc. More significantly, programmed ...