Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies.

Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas.

Model more closely replicates natural environment of the pancreas, which will be essential for studying diabetes and ...

(2) In Figures 3f and 3g, some of the ECs protruded long and intricate sprouts, and nearly all the ECs ... that the high glucose treatment induced the endothelial differentiation into tip cell-like ...

We propose that defects caused by fibrillin-1 deficiency in this transient matrix alter balanced angiogenesis by preventing proper specification of tip and stalk cells. Supplying the growing ...

2011). In response to growth factors or hypoxic conditions, endothelial cells on existing vessels begin migrating toward the growth signal and form a new vascular sprout. Over time, this sprout ...

DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States 2 Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX, United States Endothelial cells (ECs) ...

At the start of this process, some endothelial cells along the outside of an existing blood vessel turn into tip cells. These tip cells have long finger-like protrusions on their surface ...

However, to obtain a more comprehensive visualization of the sprouts only stack projections ... the capability of ECs to compete for the tip cell position during retinal angiogenesis. Impaired ...