This study aimed to investigate the involvement of planar cell polarity via the receptor ROR2 (receptor tyrosine kinase-like orphan receptor 2) in endothelial responses to laminar shear stress. We ...

Endothelial cells are generally thin and elongated. However, their cell shape and structure can change depending on their place in the body. According to research, the cells can adapt when the ...

The internalization and transport of integrin β1 towards the cell front enhance the establishment of front-rear polarity. FAT4, FAT tumor suppressor homolog 4; LEC, lymphatic endothelial cell; Mafb, ...

Endothelial cells -- the cells that line blood vessels -- grown alongside leukemia cells become corrupted and rescue the cancer cells from many chemotherapy drugs, a study found. Endothelial cells ...

Northwestern Medicine scientists developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which line blood vessel walls. Published in Cell ...

In conclusion, the in vitro and in vivo data agree on the importance of VEGFR2, specifically through pY951 signaling, in endothelial cell alignment and polarity. Moreover, the Src pathway regulates ...

including the activation of quiescent endothelial cells (ECs), cell protrusion, basal lamina and extracellular matrix degradation, cell migration and proliferation, deposition of new basement membrane ...

which are required for endothelial cell (EC) apical–basal polarity and proper deposition of the vascular basement membrane. Parvins are actin-binding proteins that facilitate the interaction of ...

CAMSAP2 was also important for persistent endothelial cell sprouting during in vivo zebrafish ... indicating that in these conditions the centrosome inhibited cell polarity. We propose that ...

In the broadest sense, this variation in shapes is known as cell polarity, and it is an essential property for a variety of cell functions. Growth in accordance with their polarity allows cells to ...

Endothelial cells forming the sprout must develop front-rear polarity to allow sprout extension. The adaptor proteins Nck1 and 2 are known regulators of cytoskeletal dynamics and polarity, but their ...