Amylyx received FDA Fast Track designation for AMX0114, an investigational antisense oligonucleotide targeting knockdown of calpain-2, for people living with amyotrophic lateral sclerosis (ALS) in ...

Research has indicated that overactive calpain-2 activity might accelerate disease progression in ALS and other neurodegenerative conditions by causing the degeneration of axons, which are vital ...

It indicated the nomenclature of the labels are consistent with biological materials related to C. elegans research. Han estimated sending five to 10 packages to the United States, according to ...

Key takeaways: AMX0114 was developed to target calpain-2, a driver of axonal neurodegeneration. A pending clinical trial will evaluate safety and efficacy of the novel therapeutic. The FDA has ...

AMX0114 is an investigational antisense oligonucleotide targeting calpain-2, a calcium-activated protease believed to play a role in ALS disease progression.

Inside the world of C. elegans worms and the scientists who know them best.

One of the simplest, most over-studied organisms in the world is the C. elegans nematode. For 13 years, a project called OpenWorm has tried—and utterly failed—to simulate it.

While there’s no cure for early onset Alzheimer’s disease, medications and supportive therapies can help manage symptoms related to memory loss, cognitive decline, and functional impairment.

After raising questions surrounding dosing levels, the FDA has freed Amylyx’s early-stage amyotrophic lateral sclerosis (ALS) candidate from a clinical hold. | After raising questions ...

A complete list of all neurology ICD-10 codes, including those for muscular dystrophy, epilepsy, encephalopathy, and other neurological conditions.

Danon disease is a rare, X-linked, monogenic cardiomyopathy caused by mutations in the lysosomal-associated membrane 2 gene (LAMP2), which encodes the LAMP2 protein. In male patients, the predomina ...

Syntichaki et al. used C. elegans having different mutated aspartyl proteases, and treated them with calpain inhibitors. They observed that neuronal degeneration inflicted by various genetic lesions ...