elegans. The worms turned out to be the perfect lab animal. They were simple creatures that lived in the dirt and ate bacteria but were just complicated enough to provide biological insights ...

elegans has shown that nematode and mammalian models of channel-mediated toxicity share a common mechanism that involves a rise in intracellular Ca 2+ and the activation of calpain and cathepsin ...

A staple in laboratories worldwide, C. elegans is “an experimental dream,” said one scientist. A staple in laboratories worldwide, C. elegans is “an experimental dream,” said one scientist.

Calpain and cathepsin proteases are key in the ... such as Caenorhabditis elegans and Drosophila melanogaster. These models should help in the dissection of the biochemistry of necrosis, providing ...

Recent studies reestablish the importance to memory processes of calpain, a protease first hypothesized to play a crucial role in memory 25 years ago. A second high-profile paper in as many months ...

"In this study, we used the nematode Caenorhabditis elegans, which is only one millimeter long and has a lifespan of only two weeks. The nematodes exhibit a variety of behaviors with their 302 ...

A nuclear hormone receptor in the nematode C. elegans senses a toxic metabolite produced by the bacterial pathogen Pseudomonas aeruginosa to activate innate immunity. These data reveal an ancient ...

[26–28] They found calpain 3 was not detected by western blotting, which is probably due to its degradation by nonsense-mediated mRNA decay. Three patients harbored two null alleles, and were ...

The late stages of muscle development turn out to be driven by a protein-degradation process that is usually associated with unhealthy cellular stress Figure 1: A scanning electron micrograph of a ...

In a recent study published in Nature Communications, researchers identify an endogenous insulin antagonist that modulates fat loss in the roundworm Caenorhabditis elegans. How is information ...