We have investigated how E1A-induced apoptosis interferes with viral ... with WT and several mutant Ad vectors at 50 plaque forming unit (PFU)/cell. At 24 hours after infection, the medium was ...

(2) Introduction of the E1A 122–129 deletion (Δ24 mutant), suggested to attenuate viral replication in cell cycle-arrested cells, did not abrogate this activity and increased the cytolytic ...