Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...

79 progress with new corticosteroid receptor-binding drugs Several compounds have been reported as a result of drug-discovery activities by both biotechnology companies and large pharmaceutical ...

Since the discovery of penicillin nearly a century ago, antimicrobial resistance (AMR) has become a stealthy, pervasive enemy ...

containing bis-macrocyclic CXCR4 chemokine receptor antagonist is shown to have improved binding properties to the receptor protein in comparison to the drug AMD3100 (Plerixafor, Mozobil). The ...

In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the effect of US waves in enhancing the drug-containing microbubbles (MBs) adhered on the AAA ...

TWEAK acts by binding to Fn14 ... Cytokine–receptor pairing: accelerating discovery of cytokine function. Nature Rev. Drug Discov. 3, 160–170 (2004).

Incorporation of receptor flexibility into computational drug discovery through the relaxed complex scheme is well suited for screening against a single binding site. In the absence of a known pocket ...

The molecular mechanisms of nicotinic receptor activation are still largely unknown. The crystallographic structure of the acetylcholine binding protein (AChBP) reveals a single H‐bond between two ...