79 progress with new corticosteroid receptor-binding drugs Several compounds have been reported as a result of drug-discovery activities by both biotechnology companies and large pharmaceutical ...

Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells ...

Since the discovery of penicillin nearly a century ago, antimicrobial resistance (AMR) has become a stealthy, pervasive enemy ...

and this peptide–receptor system has been implicated in a diverse range of biological functions including (but not limited to) pain, reward/drug abuse, cardiovascular control and immune function.

Novo Nordisk's GLP-1 receptor agonist semaglutide has been shown ... pointing to yet another potential use for the versatile drug class. The small, 48-subject study – published in the journal ...

Data Synthesis: Pharmacodynamic characteristics (glucocorticoid receptor binding) and lung delivery determine the relative clinical efficacy and pharmacokinetic properties (oral bioavailability ...

How the Fab domain of S-4321’s low-affinity binding to PD-1 sustains receptor agonism without causing target depletion ... immune modulatory programs from early target identification to drug candidate ...

The consequences of this type of binding site for protein function can begin to be assessed as more examples are found and subsequent mutagenesis studies are performed. Finally, we hope that the ...