Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

Also, these receptors respond not just to bitter-tasting substances, but to various kinds of drugs. Consequently, the dual-binding mechanism found for TAS2R14 opens up new possibilities for drug ...

In conclusion, in this 4-week trial involving patients with an acute exacerbation of schizophrenia, SEP-363856, a drug with a non–D2-receptor-binding mechanism of action but with agonist ...

They report that the receptor–drug complex includes some suprising aspects to risperidone binding, which could help to direct future design of drugs that target DRD2. “The DRD2–risperidone ...

In the paper, "Preventing skin toxicities induced by EGFR inhibitors by topically blocking drug-receptor interactions ... molecule SDT-011 reduced the binding affinity of monoclonal antibodies ...

The selectivity for M3 receptors renders tiotropium its unique clinical advantages. Drugs such as tiotropium work well because of kinetic differences – however, they were not designed that way several ...