Muscimol, a GABA-A (GABAA) receptor agonist, enhances GABA's inhibitory effect on neuronal activity by activating GABAA ...

‡ † Medicinal Chemistry, ‡ Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia *Phone: +61 ...

Toll-like receptors (TLRs) and their signalling pathways ... chemistry in the rational design of small-molecule agonists and antagonists. Agonists for TLR4, TLR7, TLR8 and TLR9 are being tested ...

Our kinetic studies have shown that BDZ-11-7 is a noncompetitive antagonist of GluA2Q homomeric receptors and prefers to inhibit the closed-channel state. However, adding another methyl group at ...

Lipophilic β-adrenergic receptor blockers might act on the brain as well as on the heart to inhibit signals of the sympathetic nervous system and cardiac inflammation with its ability to cross the ...

However, little is known about their effects on LA function. In this study we aimed to assess whether the use of beta‐blockers, when compared to other antihypertensive agents, is associated with ...

but do those neurons care about dopamine? The team showed that indeed they express “D1” receptors for the neuromodulator. Commensurate with the degree of dopamine connectivity, Ppp1r1b cells had more ...

Angiotensin receptor blockers (ARBs) are the most commonly used among blood pressure-lowering drugs worldwide, despite the absence of sound evidence of effectiveness in large and unbiased clinical ...

Recent research from Mount Sinai Hospital has revealed significant findings regarding dopamine receptors located in a previously unexplored region of the brain. This discovery offers new perspectives ...

Summary: Dopamine receptors in the ventral hippocampus play a critical role in balancing approach and avoidance behaviors, expanding understanding beyond dopamine’s known functions in reward and ...

Preclinical data have shown that cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors can inhibit tumour growth and act synergistically with oestrogen receptor antagonists to overcome endocrine therapy ...