Muscimol, a GABA-A (GABAA) receptor agonist, enhances GABA's inhibitory effect on neuronal activity by activating GABAA ...

‡ † Medicinal Chemistry, ‡ Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia *Phone: +61 ...

Toll-like receptors (TLRs) and their signalling pathways ... chemistry in the rational design of small-molecule agonists and antagonists. Agonists for TLR4, TLR7, TLR8 and TLR9 are being tested ...

Our kinetic studies have shown that BDZ-11-7 is a noncompetitive antagonist of GluA2Q homomeric receptors and prefers to inhibit the closed-channel state. However, adding another methyl group at ...