Whereas the postsynaptic antagonist actions of OPC-4392 are ... conducted at each of the known molecular isoforms of the dopamine receptors in several transfection systems, as well as at novel ...

It also develops AXS-05 (dextromethorphan-bupropion), an investigational N-methyl-D-aspartate receptor antagonist ... reuptake inhibitor and cortical dopamine modulator, which has completed ...