By fusing various versions of the Gal4 AD to a DNA-binding domain and measuring the extent to which these fusion proteins activated gene expression, they identified a 31-residue disordered minimal AD ...

Study: DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Response.Image Credit: FUN FUN PHOTO/Shutterstock. This news article was a review of a ...

Ligands for therapeutics. The estrogen receptor (ER) is a ligand-inducible transcription factor that is comprised of a central DNA binding domain, a disordered N-terminal activation function 1 ...

Transcription factors are comprised of DNA binding domains and activation domains (ADs). Together, these domains create a bridge between the target gene and coactivators which are molecules that can ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Science Translational Medicine , 2021; 13 (616) DOI: 10.1126/scitranslmed.abj1008 Cite This Page : ...

Thus, drugs that inhibit AR activity via domains other than the LBD may provide a way to inhibit the growth of drug-resistant PC. We discovered the first non-competitive, ligand-independent AR ...