Scientists have used machine learning to improve the efficacy and safety of targeted cell and gene therapies by potentially ...

The methyl-CpG-binding domain (MBD) proteins 'read' and interpret the methylation moieties on DNA, and thus are critical mediators of many epigenetic processes. Currently, the MBD family comprises ...

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...

The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

This landmark study describes the structure of the human RAD51 filament with a recombination intermediate called the displacement loop (D-loop). Using cryogenic structural, biochemical, and ...

The observed enrichment of RNAs together with their targets indicate that CHART might be combined with high-throughput sequencing to determine the genome-wide binding profile of an RNA. We tested this ...

If DNA bridges remain between chromosomes after cell division, chromosomes become improperly segregated, resulting in genetic ...

To overcome this limit, we focused on a non-IMiD domain, SALL4 zinc finger cluster four ... predicated upon several critical considerations. While the ZFC4:DNA crystal structure shares a binding ...

YB‐1 is a DNA/RNA‐binding nucleocytoplasmic shuttling protein whose regulatory effect on many DNA‐ and RNA‐dependent events is determined by its localization in the cell. Distribution of YB‐1 between ...

Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that of the TAT transduction domain. The ...