News

A liquid biopsy-based assay could detect recurrence prior to imaging in patients with resectable colorectal cancer
An ultrasensitive circulating tumor DNA (ctDNA)-based liquid biopsy assay detected signs of recurrence prior to imaging and ...
Computational tool sheds light on DNA regulation in cancer and genome editing
Researchers from the University of Eastern Finland, Aalto University and the University of Oulu have developed a new ...
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Neochromosome and Opentrons Introduce Automated Antibody Discovery Solution, Enabling Labs to Achieve Rapid, Cost-Effective In-House Development
The Opentrons Flex neoSwitch Workstation leverages Neochromosome's neoSwitch antibody discovery platform, designed to toggle between yeast surface display for binder selection and protein secretion ...
eLife23h
LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers
BP1 is a key player in DNA repair and together with BRCA1 regulate selection of DNA double strand break repair mechanisms. Localization of DNA repair factors to sites of DNA damage by 53BP1 is ...
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Metrion Biosciences launches NaV1.9 high-throughput screening assay to strengthen screening portfolio and advance research on new medicines for pain
("Metrion"), the specialist preclinical contract research organization (CRO) and a global leader in ion channel services, ...
eLife21d
Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation
A DNA-binding assay of Sld3 and its complexes with single-stranded ARS1 fragments revealed a relationship between the dissociation of Sld7–Sld3 from CMG and the unwound single-stranded DNA. These ...
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Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States Department of Computational Mathematics, Science and Engineering, Michigan ...