Chemistry World2h
The circles of DNA that cause cancer
Ring-shaped extrachromosomal DNA is implicated in many cancers. Rachel Brazil talks to the scientists trying to uncover their ...
Peptide screening reveals irreversible inhibitors for cancer's 'undruggable' cJun protein
For the first time, scientists have identified promising drug candidates that bind irreversibly with a notoriously ...
Technology Networks4d
Promising Drug Candidates Identified for Previously “Undruggable” Cancer Target
Scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein ...
News-Medical.Net on MSN4d
Scientists discover irreversible peptide inhibitors for undruggable cancer target
For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously "undruggable" cancer protein target, permanently blocking it.
eLife11d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
News-Medical.Net on MSN12d
Gilead’s capsid revolution meets our capsid solutions: Sino Biological – Engineering the tools to outsmart HIV
Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir ...
eLife6d
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
The Scientist12d
Pluripotency Superstar Oct4 Gets a Makeover
The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.