A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from ...

At the heart of this method lies the Bst DNA polymerase, whose enzymatic properties—such as strand displacement activity, thermostability, and catalytic efficiency—are critical to the success ...

Just like the government uses an Aadhaar number to uniquely identify an individual for social security purposes, a person’s DNA fingerprint can be used for biological purposes. This is why DNA ...

Using cryogenic electron microscopy (cryo-EM), researchers revealed how conformational changes in the viral DNA polymerase alter the virus’s susceptibility to drugs. The new findings further the ...

We recently reported that polymerase delta interacting protein 2 (Poldip2 ... To verify the location of the insert in vivo, we amplified genomic DNA from a heterozygous mouse, using polymerase chain ...

CNA25 strain lacks the smallest subunit of DNA polymerase delta and is avirulent. Vaccination with live CNA25 prevents a wide range of fungal infections. T cells and trained innate cells mediated ...

Alternative lengthening of telomeres (ALT) is a mechanism by which telomere length changes significantly in the absence of telomerase, the enzyme that typically maintains telomere length. ALT is a ...

Image showing polymerase theta and polymerase delta's physical association. CHAPEL HILL, N.C. – Our DNA is not indestructible. Throughout the course of our lives, DNA can break in response to ...

However, this often leaves some residual flaps of single-stranded DNA at the ends. Polymerase delta jumps in to cut the extraneous flaps, giving polymerase theta enough room to start synthesizing ...

Medical researchers have learned more about an enzyme found to be overly expressed in patients with hereditary breast cancer, ovarian cancer, and prostate cancer. Our DNA is not indestructible.

“Time is quickly running out for me,” writes a man in his mid-30s whose DNA harbors a genetic mistake certain to destroy his brain within a matter of years. “Watching my sons disintegrate ...