a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms. The study, published in Nature Communications, was conducted by researchers from ...

With Evo 2, researchers can rapidly predict protein structures and generate DNA sequences, significantly advancing the fields ...

2 The team next wanted to test these findings in a physiological context; they were curious to see how negative supercoiling, or under twisting of DNA that happens during normal transcription and ...

The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell. After that, the next step in CRISPR gene editing is usually to alter that piece of DNA. However ...

CRISPR-Cas9 is effective at generating small mutations by creating targeted double-stranded DNA (dsDNA) breaks that are then repaired by the cell’s non-homologous end-joining pathway.

Early reports have demonstrated that CRISPR effectively excises integrated human immunodeficiency virus type 1 (HIV) from cells. 1,2 For Michele Lai from the University of Pisa, these studies raised ...

Rumour had it that these sequences of DNA might help bacteria gain the upper ... Short Palindromic Repeats, or CRISPR, could be hacked to make cuts at precise sequences in the genome of any ...