When DNA is damaged, internal signals activate within the cell to pinpoint the damage and recruit specialized proteins—DNA repair "machines"—to fix the break. This repair process must be ...

revealed how a DNA-binding protein called RdfS forms helical structures or twisting forms that control the process of DNA transfer between agricultural bacteria. "DNA is literally cut out of one ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Researchers show that glycoRNAs, uncovered by the lab of Nobel Laureate, Carolyn Bertozzi, can be used to fight cancer.

The labs of Ryan Flynn at Boston Children’s Hospital and Konstantinos Tzelepis at the Cambridge Stem Cell Institute have found a readily druggable target on the surface of acute myeloid leukemia (AML) ...

The compound also enhanced the performance of the full mitochondrial replisome, including TWINKLE helicase and mitochondrial single-stranded DNA-binding protein (mtSSB). TWINKLE is a mitochondrial ...

We have shown that PEI-mannose polymers compact DNA into nanoshell-like particles, which can load proteins as well. Here we show that these DNA containers are uniquely versatile for scavenging ...

The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China The Biobank Center, The First Affiliated Hospital of ...

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their ...

This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying five novel interaction candidates, three of which are validated experimentally through ...