Researchers analyzed a library of engineered receptors derived from natural cytokine receptors, focusing on Modular ...

Upon binding to their surface receptors, cytokines trigger downstream signaling cascades associated with many cellular processes, such as differentiation, tissue repair, proliferation, migration, and ...

Cytokine bioactivity can be regulated at the levels of transcription, translation, cleavage and cellular release, as well as through receptor and post-receptor signalling mechanisms. The activity ...

G Protein-Coupled Receptors (GPCRs) in advancing GPCR-targeted therapies, including the use of agonists, antagonists, biased ...

Tocilizumab -- an interleukin (IL)-6 receptor inhibitor -- was approved ... such as giving steroids or anti-cytokine drugs as ...

Instead, the cytokine may act through other cell populations ... they isolated splenocyte populations and observed that basophils expressed high levels of IL-3 receptors. When treated with IL-3, ...

IL17 is part of a cytokine family that includes five other members: IL17B, IL17C, IL17D, IL17E/IL25 and IL17F. The sequences of IL17 and IL17F are the most similar. To signal through the receptor ...

Toll-like receptor 4 activation consequently produces an innate immune response in the brain that initiates the release of glial-derived neuroexcitatory and neurotoxic substances such as ...

Siltuximab effectively treated patients who experienced common adverse events after chimeric antigen receptor T-cell therapy ... the agent lessened severity of cytokine release syndrome or ...