During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

Cytokine actions may be autocrine meaning the cytokine acts on the same cell that secretes it. If the cytokine acts on cells nearby other than the one that secreted it, the action is termed paracrine.

Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection. It happens when an immune system communication protein called cytokine is overproduced.

Expert Rev Endocrinol Metab. 2008;3(2):147-159. Inflammatory or immunological factors appear to be implicated in insulin resistance and decreased β-cell function. [37] Compared with nondiabetic ...

Central to these processes are cytokines – soluble signaling proteins that orchestrate immune responses by mediating communication between cells. Cytokine networks exhibit dual functionality: they are ...

In a new study published in Science Immunology titled, “ An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses,” researchers from the University of Pennsylvania (Penn ...

One cytokine, two platforms. Synthekine aims to optimize IL-10, ... “Based on emerging external and internal data about non-alpha IL2’s mechanism of action and therapeutic potential, ...

MarketWatch.com ‘Cytokine Storm’ — the ‘intriguing’ similarity between COVID-19 and the 1918 influenza A hyperinflammatory immune response to the influenza of 1918 was seen as one reason ...

Cytokines are a diverse group of small protein molecules that play crucial roles in the immune system and various biological processes. They are synthesized and secreted by a range of immune cells, ...

Get Instant Summarized Text (Gist) Incorporating interleukin-12 (IL-12) into mRNA vaccines enhances CD8 + T cell responses, improving protection against SARS-CoV-2, influenza, melanoma, and ...

Cytokines are powerful regulators of the immune system and attractive therapeutic effector candidates. However, their sites of action must be restricted to avoid systemic toxicity.