CRISPRa and CRISPRi respectively. Yet others, called base editors, change one letter of the DNA code to another. So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA.

New gene transcriptional regulation tools are under development, including CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa), as well as novel Base Editor (BE), Prime Editor (PE ...

A single genetic switch could potentially treat a rare but severe childhood disorder. Prader-Willi Syndrome (PWS) affects approximately 1 in 15,000 newborns, causing insatiable hunger, obesity ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Genome-wide association studies (GWASs) have ...

The class II clustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems, characterized by a single effector protein, can be further subdivided into types II, V, and VI. The ...