Figure 1: Structures of human CPSF-73 and yeast CPSF-100 (Ydh1). Figure 2: The β-CASP domain of CPSF-73 and CPSF-100. Residues 1–460 of human CPSF-73 were sub-cloned into the pET28a vector ...

mRNA 3′-end processing requires four multiprotein cleavage factors (CPSF: cleavage and polyadenylation specificity factor; CstF: cleavage stimulation factor; CF I and II: cleavage factors I and ...

Their work also builds a basis for understanding alternative polyadenylation--a much ignored cousin of alternative splicing that helps explain how a 30,000-gene genome might produce more than 120,000 ...

At first glance, polyadenylation isn't an obvious culprit in cancer. It is an evolutionarily ancient and routine process that adds a tail of RNA nucleotide "letters"—all of them adenosines ...