The success of multiple covalent drugs against proteins once deemed “undruggable” has fueled growing interest in electrophiles that covalently bind amino acids such as cysteine. However, current ...

We collaborate with the world's leading lawyers to deliver news tailored for you. Sign Up for any (or all) of our 25+ Newsletters. Some states have laws and ethical rules regarding solicitation ...

Florida Governor Ron DeSantis wrote on X, formerly Twitter, on April 2: "I support the bill by Senator @IleanaGarciaUSA to ban geoengineering and weather modification. The Florida house ...

FMC-220 is designed to address the potency and durability challenges seen with non-covalent approaches targeting the structurally destabilized p53 Y220C mutant. Preclinical studies showed FMC-220 ...

Get Instant Summarized Text (Gist) The covalent Werner helicase inhibitor RO7589831 demonstrated early clinical efficacy and was generally well-tolerated in patients with solid tumors exhibiting ...

The research team is now investigating whether this same gene-modification approach could help treat other cancers, especially solid tumors like those found in organs, which have been particularly ...

Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, covalent modifications of core nucleosomal ... and clinical development of epigenetic and ...

Long considered simply a product of muscle metabolism and a source of energy for neurons, lactate is now recognized as an epigenetic regulator, activating gene transcription by altering chromatin ...

Histone modifications act by influencing the recruitment of non‐histone proteins and by determining the level of chromatin compaction, transcription factor binding, and transcription elongation.

As the levels of carbon dioxide in the environment rapidly rise and the climate consequences of that rise become increasingly apparent, research and investment into carbon capture strategies have ...

These modifications, which include DNA methylation, histone modifications, chromatin remodeling, and RNA modifications, are crucial for maintaining cell identity, proliferation, and ...

The evidence supporting the conclusions is convincing. Effects were shown by Hi-C as well as qPCR for chromatin modifications and expression, and the specificity of the effects was controlled by ...