Yeast, a single-cell microorganism, typically has 16 chromosomes. Using a synthetic biological technique, Yuan’s team has designed and synthesized an extra yeast chromosome in a live cell.

The team heavily edited its synthetic chromosome, altering around one-sixth of its base pairs with additions, deletions, and replacements. Despite these changes, yeast cells that carried the designer ...

Researchers identified and corrected genetic errors that impacted yeast growth ... comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome,” write the investigators.

Final synthetic yeast chromosome unlocks new era in biotechnology. ScienceDaily . Retrieved February 17, 2025 from www.sciencedaily.com / releases / 2025 / 01 / 250122125522.htm ...

The research team used specialized gene editing tools to identify and fix problems in the synthetic chromosome affecting how well the yeast could reproduce and grow under challenging conditions.

“The synthetic yeast genome represents a quantum leap in our ability ... Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome. Nat Commun.

Synthetic genomics has emerged as a transformative field, enabling the design and construction of artificial genomes to explore biological systems and enhance biomanufacturing capabilities.

The research team used specialised gene editing tools to identify and fix problems in the synthetic chromosome affecting how well the yeast could reproduce and grow under challenging conditions.

(Nanowerk News) Macquarie University researchers have worked with an international team of scientists to achieve a major milestone in synthetic biology by completing the creation of the final ...