The modification state helps determine whether the nucleosome is an appropriate substrate for a remodeler complex (Saha et al., 2006), as discussed later in this article. Chromatin structure is ...

Histones not only keep DNA organized, but also help regulate gene expression. How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell ...

configure chromatin architecture, recruit transcription factors and activate or silence individual loci or gene networks. Moreover, we can investigate the cross-talk between the genome and the ...

Inside every human cell, 2 meters of DNA must be tightly packed into a tiny nucleus. This DNA is wrapped around proteins to form chromatin, which exists in two main forms: euchromatin, where genes ...

Chromatin is the physiological state of the genome ... A major, but not exclusive focus of our lab is the analysis of histones, their variants, post-translational modifications and proteoforms.

The chromatin landscape integrates diverse cellular signals to regulate genome structure and subsequent biological functions, partly through posttranslational modifications (PTMs) on histone proteins.