This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights ...

A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Chromatin is a flexibly joined chain of nucleosomes ... showing that CODANIN-1 utilizes histone H3-mimic helices and B-domains to sequester ASF1A, thereby inhibiting ASF1 function.

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Bradley Bernstein, MD, PhD, A. Thomas Look, MD, and William R. Sellers, MD, of Dana-Farber Cancer Institute have been elected as Fellows of the ...

Department of Molecular Medicine and Cancer Research Centre, Université Laval, Quebec, QC G1V 0A6, Canada CHU de Québec Research Centre, Quebec, QC G1V 4G2, Canada PROTEO-Quebec Network for Research ...

In the study, "Genome Modeling and Design Across All Domains of Life with Evo 2," published ... to engineer DNA sequences with programmable chromatin accessibility. Integrating chromatin ...