Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

NEW YORK - Ludwig Cancer Research extends its congratulations to Ludwig Harvard's Bradley Bernstein on his election as Fellow ...

Bradley Bernstein, MD, PhD, A. Thomas Look, MD, and William R. Sellers, MD, of Dana-Farber Cancer Institute have been elected ...

tightly packed conformation in which active and inactive chromatin domains are folded together in two spatially different compartments. Although this global arrangement allows insights into ...

including the discovery of bivalent chromatin domains that regulate developmental gene activation and the role of IDH mutations in disrupting chromosomal topology, resulting in the establishment of ...

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

In the study, "Genome Modeling and Design Across All Domains of Life with Evo 2," published ... to engineer DNA sequences with programmable chromatin accessibility. Integrating chromatin ...

The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.

A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese ...

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.