New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that blocks kappa ...

Drugmakers are turning to biomarkers, like folate receptor alpha, and even cell therapies to tackle this deadly cancer in new ...

Cell and gene therapies harbor great hopes for biomedicine. They are becoming increasingly important for diseases that are ...

A new study reveals the biological secret to the Zika virus's infectious success: Zika uses host cells' own "self-care" ...

There is no highly effective vaccine against tuberculosis (TB), which remains an infection of global concern. Charles ...

Not all patients respond well to chimeric antigen receptor (CAR ... “By measuring the expression of markers on a cell’s surface, we can learn more about what distinguishes one CAR T cell ...

1 Cell signaling receptors are proteins on the cell surface or inside the cell that bind to specific signaling molecules. 1 These receptors can identify and translate different external stimuli ...

The breakthrough, described today in Nature, revolves around engineered receptors on the surface of cells that can sense molecules in the surrounding environment and, in response, change the ...

They do this by adding a gene to the T cell that causes the cell to make proteins on their surface called chimeric antigen receptors (CARs). The CARs can recognise and target a specific protein on the ...

progesterone receptor; SG, sacituzumab govitecan; TNBC, triple-negative breast cancer; TPC, treatment of physician's choice; Trop-2, trophoblast cell surface antigen 2. Consistent with the final ...

Understanding cellular decisions due to receptor–ligand interactions at cell–cell interfaces has been hampered by the difficulty of independently varying the surface density of multiple different ...

While some agreed that the sTREM2-transgelin-2 interaction reduced downstream tau pathology, others noted that transgelin-2 contains no transmembrane domain, hence cannot act as a cell-surface ...