laying the groundwork for the development of gene therapy for sickle cell disease and beta thalassemia. This new Perturb-multiome approach enables researchers to systematically reveal how ...

BCMA is selectively induced at the time of plasma cell differentiation and is almost absent on immature and memory B cells (Avery et al., 2003; Chiu et al., 2007). The communication between BCMA ...

Given the essential function of 'helper' T cells, researchers have long sought to define biological signals that encourage their development. A powerful arm of the immune system is production of ...

During normal development, insulin-expressing beta cells appear around embryonic day 13.5 (E13.5) in mice or week 8 and 9 post-conception in humans 2,3, but regulated GSIS has been observed only ...

Orvacabtagene autoleucel (orva-cel), a B-cell maturation antigen (BCMA)-directed CAR T cell therapy for patients (pts) with relapsed/refractory multiple myeloma (RRMM): update of the phase 1/2 EVOLVE ...