"These cells' maturation is arrested in the embryonic stage, even when they've grown in a dish for a year or more," says Chulan Kwon, Ph.D. , an assistant professor of medicine and member of the ...

Short-term IF boosts glucose homeostasis, but prolonged fasting in adolescence may impair β cell maturation—potentially linking chronic IF to type 1 diabetes risk. Study: Chronic intermittent ...

laying the groundwork for the development of gene therapy for sickle cell disease and beta thalassemia. This new Perturb-multiome approach enables researchers to systematically reveal how ...

So B-cell maturation antigen is an evolving field where we have three ways of targeting this receptor, including the antibody direct conjugate, as well as the chimeric antigen receptor T-cell ...

While current therapeutic options include chemotherapy and immunotherapy, this study opens new avenues for novel approaches aiming at restoring normal B cell maturation. The team, spearheaded by ...

Orvacabtagene autoleucel (orva-cel), a B-cell maturation antigen (BCMA)-directed CAR T cell therapy for patients (pts) with relapsed/refractory multiple myeloma (RRMM): update of the phase 1/2 EVOLVE ...

More than 400 people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukemia (B-ALL) next year in Spain, according to the latest projections from ...