Proteolysis Targeting Chimeras (PROTAC): Bifunctional molecules designed to induce the degradation of specific proteins by harnessing the ubiquitin-proteasome system. Celastrol and Its Effects on ...

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...

Polyubiquitination targets proteins for recognition and processing by the 26S proteasome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recycles ubiquitin.

As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and ...

The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation and turnover, of many proteins vital to cellular regulation and function. The UPS comprises a sequential series ...

“Their world-renowned expertise in clinical oncology, drug discovery and development, and the basic-science of the ubiquitin-proteasome system will be invaluable as we both advance drug ...

The protein tagged with ubiquitins is referred to as a polyubiquitin chain and this is bound by the proteasome for degradation. This overall process of protein degradation is termed the ubiquitin ...

And while cells typically tag proteins destined for proteasomal destruction with the small molecule ubiquitin, the newly reported study found that midnolin-proteasome mechanism bypasses this ...

The big biotech firm Celgene will work with San Francisco-based Nurix to develop small molecules that function through the ubiquitin-proteasome system (UPS) to modulate protein homeostatis.

In this new editorial, researchers Xiaoling Li and Ping Mu from the University of Southwestern Medical Center discuss the ubiquitin-proteasome system (UPS), which is usually responsible for ...

For more than a decade, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.