This review summarizes the latest literature regarding the specific E3 ligases involved in heart biology, and the general ways that the proteasome regulates protein quality control in heart disease.

Background: Celastrol is an effective component of the plant Tripterygium ... target the degradation of CHEK1 and PIK3R2 proteins in MDA-MB-231 cells in a ubiquitin-proteasome dependent manner, ...

The aim of vepdegestrant is to recruit the ubiquitin proteasome system to degrade the ER. Pfizer got in on the action back in 2021, and the companies have previously announced plans to combine ...

Most unwanted cellular proteins are earmarked for proteasome-mediated degradation by multimers of the protein ubiquitin, which binds to ubiquitin receptors on the proteasome. Some proteins, however, ...

In fact, Diogo Feleciano, PhD, one of the co-founders and the CSO of a new biotech startup Booster Therapeutics said that his company’s proteasome activation approach offers important advantages ...

Triplet or quadruplet therapies incorporating proteasome inhibitors, immunomodulators, and anti-CD38 antibodies have led to prolonged survival among patients with newly diagnosed multiple myeloma ...

This vital task falls upon specialized enzymes known as ubiquitin ligases, which tag obsolete proteins for degradation, guiding them to the cellular recycling center, the proteasome. Ubiquitin ...

And while cells typically tag proteins destined for proteasomal destruction with the small molecule ubiquitin, the newly reported study found that midnolin-proteasome mechanism bypasses this ...

For more than a decade, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.

Researchers at the University of Copenhagen report in Nature Chemistry on the biosynthetic pathway of a molecule called celastrol, finding to their surprise that the last few synthetic steps can ...