Here, we will review principles of ubiquitin‐dependent control of gene expression and discuss how breakdown of these regulatory circuits leads to a wide array of human diseases.

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes ...

Thus, we hypothesize that mDia2 may have other unappreciated functions and regulatory modes. Here we identify and validate proteasome and Ubiquitin as mDia2-interacting partners using stable isotope ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Among these are the chaperones, which include the heat shock proteins (HSP), the ubiquitin proteasome system (UPS), the autophagy–lysosome pathway, and the endoplasmic reticulum (ER)–associated ...

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People’s Republic of China Zhejiang Key Laboratory of Precise Diagnosis ...

Cleavage of YB‐1 by the 20S proteasome in vitro appears to be ubiquitin‐ and ATP‐independent, and is abolished by the association of YB‐1 with messenger RNA. We also found that genotoxic stress ...

1 State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China 2 Haihe Laboratory of Modern Chinese Medicine, Tianjin University of ...