Background: Celastrol is an effective component of the plant Tripterygium ... target the degradation of CHEK1 and PIK3R2 proteins in MDA-MB-231 cells in a ubiquitin-proteasome dependent manner, ...

A new strategy for delivering bulky PROTACs to cancerous cells successfully utilizes the CD36 protein pathway on cells’ surfaces.

Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship Bispecific antibodies (bsAbs) have emerged as a novel class of therapeutics, ...

"Cells have two important 'junk compartments': the lysosome and the proteasome," Silverman said. "They collect junk and other components that are not useful to the cell, chew them up and get rid ...

It moves around looking for damaged mitochondria, and when it finds them, it creates a protein called ubiquitin that signals the body to get rid of them. When that PINK1 protein mutates ...

binding to both a target protein and a ligase to drive ubiquitination and catalytic degradation of the target through the proteasome. The new deg suffix is an important recognition that the ...

in MagnetisMM-5 as a therapy for relapsed/refractory multiple myeloma in patients previously treated with lenalidomide and a proteasome inhibitor. Among the new phase 3 starts are CDK4 inhibitor ...

A pinched nerve occurs when there is pressure or force on an area of a nerve, causing it to send pain signals to the brain. Most cases are mild, and a person can often treat them at home. In this ...

Taken together, these findings demonstrate that interferon triggers PARP14-mediated ADP-ribosylation in p62 bodies, which requires an active ubiquitin-proteasome system. Interferon induces the ...