Many patients do not respond well to immunotherapy, said Professor Gareth Thomas, who led the study and has been examining the types of cells that surround tumors—cancer-associated fibroblasts ...

The study focused on fibroblasts, cells that comprise connective tissue and secrete collagen. One subtype of fibroblasts, cancer-associated fibroblasts (CAFs), play a pivotal role in promoting tumor ...

Cancer-associated fibroblasts (CAFs) are crucial in melanoma metastasis, influencing tumor microenvironments and patient outcomes, especially in immunotherapy contexts. Single-cell RNA sequencing ...

These cells, called cancer-associated fibroblasts (CAF), play an important role in how the cancer develops. Several types of CAF stimulate the growth of cancer cells and contribute to the cancer ...