Researchers have discovered a previously unknown type of connective tissue cells that surround cancer cells in pancreatic tumors. The newly discovered cells counteract tumor development and may ...

Cancer-associated fibroblasts (CAFs) are an important component in solid tumors. They play a decisive role in cancer development and have a significant influence on the success of therapy. The ...

Chemokines, our body's chemical messengers, play a crucial role in regulating the immune response.  They are secreted by ...

"The stroma is considered a key component in the aggressive nature of pancreatic cancer, as it interacts with tumor cells, protects them, and hinders the action of drugs. Moreover, stromal cells, ...

Study Identifies Subtypes of Fibroblasts in Skin Cancer Nov. 19, 2024 — A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes ...

Some cancer cells circumvent GOT2 loss through macropinocytosis or by acquiring metabolites from cancer-associated fibroblasts, allowing them to replenish aspartate independently.

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...

The TME is a complex and dynamic environment incorporating not only the cancer cells but also surrounding cancer-associated fibroblasts, immune cells, extracellular matrix components and other ...

Researchers at Umeå University, Sweden, have discovered a previously unknown type of connective tissue cells that surround ...