Understanding the pathways modulated by calpain might be instrumental in ... phospho-FoxO3A-Thr 32 and PP2Ac (Upstate Cell Signaling, Lake Placid, NY, USA), Akt detection kit (Cell Signaling ...

In neurons, mitogen-activated protein kinase (MAPK) regulates a variety of signal transduction pathways, including those involved ... the proteasome, or calpain might be the proteolytic culprit.

The authors therefore suggest that calpain inhibitors improve memory in APP/PS1 mice because they reestablish normal signaling between nerve cells.

Calpains are Ca 2+-dependent cysteine proteases (proteolytic enzymes with cysteine in the catalytic site) that modulate cellular function. In humans, 14 independent genes encode members of the ...

The authors therefore suggest that calpain inhibitors improve memory in APP/PS1 mice because they reestablish normal signaling between nerve cells. TITLE: Inhibition of calpains improves memory ...