As an example, Atg5 is an essential autophagy inducer, yet it can be cleaved by calpain cysteine ... the development of mouse model systems that use a conditional knockout approach to delete ...

In subsequent studies, extracellular signal-regulated protein kinase 5 (ERK5) cardiomyocyte-specific knockout mice (ERK5-cko ... after saturated fatty acid treatment was mediated by calpain-1, while ...

Mouse models for hemophilia A are commonly generated by factor VIII (FVIII) knockout, however, these mice rapidly develop anti-FVIII antibodies during repetitive FVIII administration. To overcome this ...

Li and his colleagues took a different approach. The team used gene editing to knock out imprinted genes altogether. Around 200 of a mouse’s genes are imprinted, but Li’s team focused on 20 ...

The Champions League knockout stage is officially underway. / IMAGO/ABACAPRES After a lengthy league phase, the 2024–25 Champions League knockout stage is finally here with eight matches kicking ...

Chronic stress, in particular, has been linked with many negative health outcomes—and a new study published February 11 in PLOS Biology finds that in mice, at least, it can also affect the way ...

Now, researchers have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects. Despite ...

Paulo Henrique Laia vs. Vladimir Kanunnikov at LFA 201 was overturned after Kanunnikov secured the knockout on his opponent while grabbing him by the throat. Laia vs. Kannunikov was a once-in-a ...

Born as a pandemic diversion in 2020, “Knockout” is finally a fully baked dance performance, premiering with a two-week run kicking off the spring edition of Steppenwolf’s LookOut Series.