Nature22d
Calpain Proteases and Their Role in Cell Death and Disease
Specifically, calpain-1 and calpain-2 have been linked to tumorigenesis ... Efforts are underway to develop calpain-specific inhibitors that could potentially block the progression of aggressive ...
Nature11d
Self-eating and self-killing: crosstalk between autophagy and apoptosis
As an example, Atg5 is an essential autophagy inducer, yet it can be cleaved by calpain cysteine proteases to lose its pro-autophagy effects and become a pro-apoptotic molecule. Beclin-1 (or its ...
Healio13d
SGLT2 inhibitors may offer more cardioprotective benefits than GLP-1s for older adults
GLP-1 receptor agonists conferred greater HbA1c reductions in older adults than younger adults. Older adults had a lower risk for major adverse CV events than younger adults with SGLT2 inhibitors.
Clinical trial finds RNA inhibitor effectively reduces 'bad cholesterol' in patients with cardiovascular disease
The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of ...
Science Daily11d
Inhibitor drugs to treat aggressive breast cancer identified
A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.
Neurology Advisor12d
GLP-1 Receptor Agonists Tied to Risks and Benefits Beyond Weight Loss
The authors used the U.S. Department of Veterans Affairs databases to build a cohort of people with diabetes who initiated a GLP-1 RA and compared them to patients initiating sulfonylureas, dipeptidyl ...
Business Wire7d
AceLink Therapeutics Presents Interim Results from a Phase 2 Trial of the GCS Inhibitor AL01211 in Treatment-Naïve, Classic Male Fabry Disease Patients at the WORLD Symposium 2025
AceLink Therapeutics, Inc., a clinical-stage biotech company developing next-generation oral substrate reduction therapies (SRTs), presented interim d ...
Study uncovers two inhibitors to halt metaplastic breast cancer progression
A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.
The Lancet12d
Aromatase inhibitors, cardiovascular medications, and patient outcomes
We read with interest the article by Marie Lund and colleagues published in The Lancet Oncology investigating the association ...
pharmaphorum3d
Opdivo's subcutaneous PD-1 inhibitor cleared in US
It is the second drug in the PD-1/PD-L1 inhibitor class to be cleared in a subcutaneous injection form by the FDA after Roche's Tecentriq Hybreza (atezolizumab and hyaluronidase) – which got a ...
Cullgen begins Phase 1 dosing of oral, pan-TRK protein degrader
Cullgen announced that it has begun dosing in human subjects to evaluate its potential first-in-class, oral, pan-TRK protein degrader for the ...
Frontiers13d
A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival
Demethylation is controlled by an esterase, PP2A methylesterase (PME-1). We tested two potential LCMT-1 small molecule inhibitors and found that methyl ...