The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of ...

Perioperative chemotherapy with either S-1 or 5-fluorouracil plus oxaliplatin and docetaxel for locally advanced gastric or gastroesophageal junction adenocarcinoma: A prospective trial and matched ...

In nearly every way that matters, the new Z6 III matches or outperforms the company's much pricier, top-end Nikon Z8. Although it's not perfect, the Z6 III is one of the best full-frame mirrorless ...

Memantine has been assessed for use in human glaucoma, with two parallel, double-masked, placebo-controlled three-armed Phase III clinical trials, each with more than 1000 patients, to examine the ...

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China Department of Medicinal Chemistry, School ...

These next-generation STAT6 inhibitors demonstrate excellent oral bioavailability, cell permeability, and metabolic stability, and do not target STAT6 for degradation. DeepCure expects to select a ...

(iii) Autophagy: Calpain inhibits autophagy by cleavage of Beclin-1 and ... mPTP, mitochondrial permeability transition pore; ATP5A1, ATP synthase subunit α; IAPs, inhibitor apoptosis protein; ATG, ...

LGMDR1 is caused by mutations in the CAPN3 gene that encodes calpain 3 (CAPN3), a non-lysosomal cysteine ... Treatment with the proteasome inhibitor bortezomib (Velcade) increased SERCA2 protein ...