As an example, Atg5 is an essential autophagy inducer, yet it can be cleaved by calpain cysteine proteases ... as caspases), so far no pharmacological inhibitors (that would act with an acceptable ...

The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of ...

Researchers are investigating selective calpain inhibitors as potential therapeutic agents to prevent calpain-mediated apoptosis in degenerating neurons, which could lead to new treatment ...

The suzetrigine, which only acts on pain neurons, is the first innovation in analgesia in the last 20 years. "It stands out ...

One area where the Blazers could significantly benefit is with the potential return of Robert Williams III, who has been sidelined due to right-hand soreness. Williams, who has missed the past ...

Wonder Land: Donald Trump used to be accused of breaking norms. Now it’s ‘disruption.’ Question is: will this approach work in 2025? The answer doesn’t break easily into yes or no. Photo ...

This review explores the range of small molecule, peptide and antibody inhibitors targeting molecules involved in anoikis resistance in melanoma, and may be repurposed to prevent metastatic melanoma ...

(ii) SCPs give rise to immature Schwann cells (E14.5); and (iii) immature Schwann cells give rise to pro ... cells over 4 weeks using a combination of chemical small molecule inhibitors including a ...

68–69] III: cell culture and mice transfected with an HBV plasmid (small animal model): [102–104] 3TC: Lamivudine; cccDNA: Covalently closed circular DNA; CHB: Chronic HBV; Cp: HBV core ...

Treatment with HU + CDK2 inhibitor specifically enriches for the transient configurations of Stage 1, while HU treatment alone enriches for Stage 2. Untreated cells display a mixture of engagement ...

School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U.K. School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U ...