This attachment not only blocks the portion of the enzyme called the active site, where calpain performs its snipping function, but also covers regions away from that site. Such a broad molecular ...

In early work, it was thought that when a calpain binds to the plasma membrane, it is transformed from an inactive, proenzyme into an active, proteolytic enzyme by autolysis. However, other ...

Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state, and has been implicated in several diseases.

A central question has been how calpastatin is so exquisitely specific in attaching to calpain and inhibiting it—essentially ignoring other highly similar enzymes in the cell. In an article ...

Lynch said studies have shown that an enzyme called calpain is responsible for breaking down the proteins of brain cells, allowing them to form new connections. These new connections, or new ...

New research could pave the way for treating malaria, among other serious diseases, by using a method that inhibits a particular calcium-regulated enzyme called calpain. While the enzyme is ...

They hoped the toxic enzyme calpain would latch on to the decoy instead of the actual receptor, averting brain damage. As a test, the researchers then injected the mice with kainic acid ...

Researchers found that a mutation in the CAPN1 gene disrupts the function of an enzyme called calpain-1 and causes abnormal brain development in humans, mice and Parson Russell Terrier dogs.

PHILADELPHIA — Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state. It has been implicated as a factor in ...